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Nexgard Spectra dog 30-60 kg (against fleas, ticks, and worms)
Nexgard Spectra refers to combined antiparasitic drugs. The active ingredients of the drug, afoxolaner and milbemycin oxime, provide a wide range of antiparasitic effects against ectoparasites and nematodes that parasitize dogs.:
- fleas (Ctenocephalides felis, Ctenocephalides canis);
- Ixodes mites (Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Amblyomma americanum, Ixodes hexagonus);
- Demodectic mites (Demodex canis);
- scabies mites (Sarcoptes scabiei, Otodectes cynotis);
- gastrointestinal nematodes (Tochosaga canis, Toxascaris leonina, Ancylostoma caninum, Ancylostoma braziliense, Trichuris vulpis);
- nematodes of the esophagus (Spirocerca lupi);
- pulmonary nematodes (Ancylostoma ceylanicum, Angiostrongylus vasorum);
- nematodes of the visual organs (Thelazia callipaeda adult forms);
- larvae of Dirofilaria (Dirofilaria immitis);
- mosquitoes (Aedes aegypti).
Afoxolaner is an insecticide of the isoxazoline group; its mechanism of action consists of blocking GABA-dependent arthropod receptors, hyperexcitation of neurons, and disruption of nerve impulse transmission, which leads to paralysis and death of ectoparasites. After oral administration, afoxolaner is easily absorbed into the gastrointestinal tract and reaches the systemic bloodstream. The maximum plasma concentration is noted 2-4 hours after administration, and bioavailability is 88%. Afoxolaner is slowly metabolized to form hydroxylated compounds and is excreted from the body mainly in bile and slightly in urine. The half-life of afoxolaner is 14 days.
Milbemycin oxime is a macrocyclic lactone active against larvae and imago of nematodes parasitizing the gastrointestinal tract of dogs, as well as larvae of Dirofilaria immitis. The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes to chlorine (CL) ions, which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis, and death of the parasite. The maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 1-2 hours, bioavailability is 81%. The compound is mainly excreted unchanged from the body, with a half-life of about 1.5 days.
Nexgard Spectra contains as active ingredients afoxolaner — 1.87% (in 1 tablet 9.4 mg, 18.8 mg, 37.5 mg, 75 mg and 150 mg) and milbemycin oxime - 0.38% (in 1 tablet 1.9 mg, 3.8 mg, 7.5 mg, 15 mg and 30 mg), as well as excipients: corn starch, soy protein flour, a food additive with the aroma and taste of beef stew, povidone E1201, macrogol 400, macrogol 4000, macrogol 15 hydroxystearate, glycerol, medium chain triglyceride, citric acid monohydrate, butylhydroxytoluene.
Nexgard Spectra is administered to dogs individually orally once at a dose of 2.5 - 5.36 mg of afoxolaner and 0.5 - 1.07 mg of milbemycin oxime per 1 kg of animal weight according to the table
| Dog weight (kg) | Tablet weight (g) | Dose of active ingredients (mg/tablet) | Dose of active ingredients (mg/tablet) | ||
| afoxolaner | Milbemycin oxime | ||||
| 2-3,5 | 0,5 | 9,4 | 1,9 | ||
| 3,7-7,5 | 1,0 | 18,8 | 3,8 | ||
| 7,5-15 | 2,0 | 37,5 | 7,5 | ||
| 15-30 | 4,0 | 75,0 | 15,0 | ||
| 30-60 | 8,0 | 150,0 | 30,0 |
When using the drug for dogs weighing more than 60 kg, a combination of tablets should be used, at the rate of 2.5 - 5.36 mg of afoxolaner and 0.5 - 1.07 mg of milbemycin oxime per 1 kg of body weight. It is not allowed to break the tablets when selecting the dose of the drug. Nexgard Spectra has an attractive aroma and taste and, as a rule, is readily eaten by dogs; otherwise, the drug is fed in a mixture with food. Make sure that the dog has completely swallowed the required dose of the drug.
The insecticidal effect of the drug begins 30 minutes after its oral administration, and the death of fleas and ixodes ticks on the animal occurs respectively for 6 hours and 24 hours. A single application of the drug prevents repeated infestation for 1 month; flea death occurs before egg laying, which prevents contamination of the premises with eggs and insect larvae. Contraindications to use are increased individual sensitivity of the animal to the components of the drug, severe liver and kidney dysfunction. The drug should not be used in patients with infectious diseases and weakened animals, dogs under the age of 8 weeks and/or weighing less than 2 kg, as well as animals of other species. For puppies of dog breeds sensitive to macrocyclic lactones, including collie, bobtail, and sheltie, the drug is used on the recommendation of a veterinarian. For pregnant and lactating bitches, Nexgard Spectra is used for vital indications on the recommendation of a veterinarian.
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