Dexinel Plus Dog Tab 10 kg (for worms)
Dexinel plus dog tab 10 kg - A broad-spectrum drug against intestinal helminths in medium- and small-breed dogs. It is used in dogs for prophylactic and therapeutic purposes for nematodosis (toxocariasis, toxascariasis, uncinariasis, ancylostomiasis, trichuriasis), cestodiasis (taeniasis, dipylidiasis, echinococcosis, diphyllobothriasis, mesocestodiasis), and giardiasis (giardiasis).
The combination of febantel, pyrantel embonate, and praziquantel provides a broad-spectrum anthelmintic action against nematodes, cestodes, and protozoa of the genus Giardia (Giardia spp.) parasitizing the gastrointestinal tract of dogs.
Febantel, a component of this drug, belongs to the probenzimidazole group and is active against nematodes of the genera Ancylostoma, Uncinaria, Toxocara, Toxascaris, and Trichocephalus. Febantel's mechanism of action involves inhibiting tubulin protein synthesis and disrupting microtubule function in nematodes, reducing the activity of fumarate reductase, a key enzyme in helminth energy metabolism, and stopping glucose transport and absorption, which causes nematode death. It is moderately absorbed in the gastrointestinal tract and is biotransformed in the liver.
Pyrantel embonate belongs to the pyrimidine group and is very poorly absorbed when administered orally, exerting its action primarily in the gastrointestinal tract. It has a broad spectrum of nematicidal activity and is active against nematodes of the genera Ascaris, Toxascaris, Ancylostoma, Uncinaria, and others. It blocks neuromuscular transmission in nematodes and causes muscle paralysis in the helminth.
Praziquantel, a pyrazinoisoquinoline derivative, is lethal to all stages of development of roundworms and tapeworms infecting dogs, including Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Trichuris vulpis, Echinococcus granulosus, Echinococcus multilocularis, Diphyllobothrium latum, Dipylidium caninum, Multiceps multiceps, and Taenia spp. Praziquantel's mechanism of action involves inhibiting fumarate reductase activity, disrupting cell membrane permeability and muscle innervation, leading to paralysis and death of the helminth. Praziquantel is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 60 minutes. It is eliminated from the body primarily in urine within 24 hours.
active ingredients in one tablet: febantel – 150 mg, pyrantel embonate – 144 mg, praziquantel – 50 mg.
excipients: lactose monohydrate, corn starch, povidone K30, sodium lauryl sulfate, microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate.
the drug is administered to large-breed dogs individually, orally, once during the morning feeding at a dose of 1 tablet per 10 kg of body weight. for the treatment of giardiasis, the drug is given at the recommended dose for 3 consecutive days. no fasting or use of laxatives is required before administration. in cases of heavy nematode infestation, a repeat dose is recommended after 14 days. for therapeutic purposes, deworming is done based on indications; for preventive purposes, it is carried out quarterly, as well as before vaccination and mating, at the therapeutic dose.
| Dog weight, kg | Number of tablets |
| 0,5 – 5 | 1/2 |
| 6 – 10 | 1 |
| 11 – 15 | 1+1/2 |
| 16 – 20 | 2 |
Contraindications include hypersensitivity to any of the drug's components. This medication is not recommended for dogs weighing less than 17.5 kg.
This medication is not recommended for use in puppies during the first three weeks of life or in pregnant bitches during the first two-thirds of pregnancy. This medication is approved for use in lactating females.
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